Washington — Marty Makary resigned as commissioner of the Food and Drug Administration on Tuesday, according to two sources familiar with the matter, stepping aside amid a swirl of reports that his tenure was coming to an end over internal policy disagreements.
His departure follows reports of conflict and tension over the FDA’s agenda. On May 6, the FDA approved some flavored e-cigarettes from the vaping company Glas Inc., and touted its safety restrictions to limit use by young people. According to The Wall Street Journal, the move came only after Mr. Trump pressured Makary to approve the fruit-flavored vapes, which he had been refusing to do.
One of the sources said Makary is leaving over the e-cigarette dispute, adding that Makary didn’t want to approve the flavored varieties but had been forced to by other members of the administration.
CBS News and other outlets had reported in recent days that President Trump had signed off on a plan to fire him. Makary didn’t appear Monday in the Oval Office alongside the president and other top public health officials for an event on maternal health.
His departure is the latest shakeup within the Department of Health and Human Services, which oversees the FDA. Vaccines chief Vinay Prasad — an ally of Makary — recently departed for a second time.
Makary was expected to testify on Capitol Hill on Wednesday. Kyle Diamantés, who is expected to assume the role of acting commissioner, is expected to testify in Makary’s place, according to one source.
The FDA commissioner is responsible for overseeing and regulating drugs, vaccines and tobacco, among other things. The FDA regulates one-fifth of consumer spending in the U.S., making it a powerful agency within American public health.
Makary, a British-American surgeon, was confirmed to the post in March 2025. He was an avid supporter of the Make America Healthy Again movement and had been highly critical of the federal response to the COVID-19 pandemic.
The vaping issue wasn’t the only one that caused friction for Makary. Conservatives and anti-abortion groups also sought Makary’s ouster after pressing the FDA to take action on the abortion drug mifepristone.
In 2021, the Biden administration made it possible for women to receive the pills via telehealth and by mail. The majority of women who terminate pregnancies do so through medication abortions.
Last June, Health and Human Services Secretary Robert F. Kennedy Jr. asked Makary to review mifepristone to examine “real-world outcomes and evidence, relating to the safety and efficacy of the drug.”
In December, there were reports he had slow-walked the study, and soon afterward, Susan B. Anthony Pro-Life America and other conservatives called for Makary’s firing.
The group called for an immediate study and went on to accuse Makary of “severely undermining” Mr. Trump and Vance on the issue.
“Makary must go,” SBA Pro-Life America said at the time.